In a rare speech on Sunday, the monarch thanked people for following government rules to stay at home and praised those "coming together to help others", the Swaziland News has learned through information sourced from the BBC.
She also thanked key workers, saying"every hour" of work "brings us closer to a return to more normal times".
It comes as the number of people to die with the virus in the UK reached 4,934.
"While we have faced challenges before, this one is different," the Queen said.
"This time we join with all nations across the globe in a common endeavour, using the great advances of science and our instinctive compassion to heal. We will succeed - and that success will belong to every one of us.
"We should take comfort that while we may have more still to endure, better days will return: we will be with our friends again; we will be with our families again; we will meet again."
The Queen, 93, also said the "painful sense of separation from their loved ones" that social distancing was causing for people reminded her of the experience child evacuees had during the Second World War.
"Now, as then, we know, deep down, that it is the right thing to do," she said.